{"id":143573,"date":"2019-05-29T10:43:01","date_gmt":"2019-05-29T12:43:01","guid":{"rendered":"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisconovo\/?p=143573"},"modified":"2023-02-07T08:59:35","modified_gmt":"2023-02-07T10:59:35","slug":"linfopoiese","status":"publish","type":"post","link":"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisconovo\/saude-e-bem-estar\/saude\/linfopoiese","title":{"rendered":"Linfopoiese"},"content":{"rendered":"

Linfopoiese – Defini\u00e7\u00e3o<\/strong><\/p>\n

A\u00a0linfopoiese<\/strong>\u00a0\u00e9 uma sequ\u00eancia de eventos rigidamente regulada que leva \u00e0 express\u00e3o de um receptor de ant\u00edgeno funcional na superf\u00edcie do linf\u00f3cito.<\/p>\n

A\u00a0linfopoiese<\/strong>\u00a0\u00e9 a forma\u00e7\u00e3o de\u00a0linf\u00f3citos<\/strong>\u00a0ou\u00a0tecido linf\u00e1tico<\/strong>.<\/p>\n

A\u00a0linfopoiese<\/strong>\u00a0\u00e9 o processo de produ\u00e7\u00e3o de\u00a0linf\u00f3citos<\/strong>, que ocorre na medula \u00f3ssea, bem como nos g\u00e2nglios linf\u00e1ticos, ba\u00e7o, gl\u00e2ndula timo e parede intestinal.<\/p>\n

Linfopoiese<\/strong>\u00a0\u00e9 o processo no qual os\u00a0linf\u00f3citos (c\u00e9lulas B, c\u00e9lulas T e c\u00e9lulas NK)\u00a0<\/strong>se desenvolvem a partir de c\u00e9lulas progenitoras.<\/p>\n

A\u00a0linfopoiese\u00a0<\/strong>de c\u00e9lulas B \u00e9 completada na medula \u00f3ssea, enquanto a\u00a0linfopoiese de c\u00e9lulas T<\/strong>\u00a0ocorre no timo.<\/p>\n

Linfopoiese – O que \u00e9<\/strong><\/p>\n

Em imunologia, os gl\u00f3bulos brancos podem ser classificados como neutr\u00f3filos polimorfonucleares, bas\u00f3filos polimorfonucleares, eosin\u00f3filos polimorfonucleares, mon\u00f3citos, linf\u00f3citos ou plasm\u00f3citos.<\/p>\n

Linfopoiese \u00e9 o processo de produ\u00e7\u00e3o de linf\u00f3citos<\/strong>, como c\u00e9lulas B, c\u00e9lulas T e c\u00e9lulas natural killer, na medula \u00f3ssea.<\/p>\n

Nesse processo, c\u00e9lulas progenitoras na medula \u00f3ssea se diferenciam em\u00a0linf\u00f3citos<\/strong>.<\/p>\n

A\u00a0linfopoiese<\/strong>\u00a0\u00e9 necess\u00e1ria para a sobreviv\u00eancia, porque os\u00a0linf\u00f3citos<\/strong>\u00a0maduros s\u00e3o elementos essenciais do sistema linf\u00e1tico do corpo.<\/p>\n

O termo formal para a\u00a0linfopoiese \u00e9 a hematopoiese linfoide<\/strong>, que basicamente significa a produ\u00e7\u00e3o de c\u00e9lulas sangu\u00edneas chamadas\u00a0linf\u00f3citos<\/strong>.<\/p>\n

As c\u00e9lulas indiferenciadas, chamadas de c\u00e9lulas-tronco hematopoi\u00e9ticas pluripotenciais, na medula \u00f3ssea podem sofrer uma s\u00e9rie de divis\u00f5es e diferencia\u00e7\u00f5es celulares antes de se comprometerem com a produ\u00e7\u00e3o de gl\u00f3bulos vermelhos, miel\u00f3citos ou linf\u00f3citos.<\/p>\n

Na\u00a0linfopoiese<\/strong>, a c\u00e9lula-tronco hematopoi\u00e9tica pluripotencial d\u00e1 origem \u00e0 c\u00e9lula progenitora multipotente. Esta c\u00e9lula d\u00e1 origem ao progenitor linf\u00f3ide inicial, que por sua vez d\u00e1 origem ao progenitor linfoide comum (CLP).<\/p>\n

O progenitor linfoide comum pode originar c\u00e9lulas natural killer (NK), c\u00e9lulas dendr\u00edticas e prolinf\u00f3citos.<\/p>\n

Na\u00a0linfopoiese das c\u00e9lulas T<\/strong>, os\u00a0linf\u00f3citos<\/strong>\u00a0s\u00e3o formados primeiramente na medula \u00f3ssea e s\u00e3o ent\u00e3o transportados para o c\u00f3rtex t\u00edmico, onde s\u00e3o submetidos \u00e0 matura\u00e7\u00e3o.<\/p>\n

As c\u00e9lulas T no timo permanecem em um ambiente livre de ant\u00edgeno por quase uma semana. Apenas 2 a 4% da popula\u00e7\u00e3o original de c\u00e9lulas T \u00e9 capaz de sobreviver nesse ambiente.<\/p>\n

Outras c\u00e9lulas T sofrem apoptose ou s\u00e3o comidas e destru\u00eddas por macr\u00f3fagos.<\/p>\n

A morte desta grande quantidade de\u00a0linf\u00f3citos T<\/strong>\u00a0assegura que os linf\u00f3citos sobreviventes possam reconhecer complexos de histocompatibilidade auto-importantes (MHC).<\/p>\n

O reconhecimento desse complexo impede a destrui\u00e7\u00e3o autoimune das c\u00e9lulas do pr\u00f3prio corpo.<\/p>\n

As c\u00e9lulas T ou tim\u00f3citos podem diferenciar-se em c\u00e9lulas auxiliares T (Th), c\u00e9lulas T citot\u00f3xicas (Tc), c\u00e9lulas T de mem\u00f3ria e c\u00e9lulas T supressoras ou reguladoras.<\/p>\n

Na\u00a0linfopoiese das c\u00e9lulas B<\/strong>, os linf\u00f3citos B s\u00e3o inicialmente formados na medula \u00f3ssea. Quando a medula \u00f3ssea est\u00e1 comprometida, o ba\u00e7o pode assumir essa fun\u00e7\u00e3o.<\/p>\n

Os primeiros estudos em c\u00e9lulas B foram feitos na bursa de Fabricus presente em galinhas, e \u00e9 por isso que eles s\u00e3o chamados de c\u00e9lulas B. Ap\u00f3s a forma\u00e7\u00e3o, as c\u00e9lulas B s\u00e3o ent\u00e3o transportadas para os linfonodos e introduzidas nos ant\u00edgenos.<\/p>\n

O reconhecimento de ant\u00edgeno \u00e9 uma importante fun\u00e7\u00e3o das c\u00e9lulas B. Uma vez que uma c\u00e9lula B reconhece um ant\u00edgeno, ela se torna ativada e se diferencia na c\u00e9lula plasm\u00e1tica, uma c\u00e9lula secretor de anticorpos.<\/p>\n

Anticorpos ligam o ant\u00edgeno e estimulam mecanismos destrutivos, como o sistema complemento e a fagocitose macrof\u00e1gica.<\/p>\n

O anticorpo mais comum secretado \u00e9 a imunoglobulina G (IgG).<\/p>\n

Outros anticorpos, tais como imunoglobulina A (IgA), imunoglobulina E ( IgE ) e imunoglobulina M (IgM), tamb\u00e9m podem ser fabricados por c\u00e9lulas B maduras.<\/p>\n

Linfopoiese – Processo<\/strong><\/p>\n

\"\"
\nLinfoblasto<\/strong><\/p>\n

\"\"
\nProlinf\u00f3cito<\/strong><\/p>\n

\"\"
\nLinf\u00f3cito m\u00e9dio<\/strong><\/p>\n

\"\"
\nLinf\u00f3cito pequeno<\/strong><\/p>\n

\"\"
\nPlasm\u00f3cito<\/strong><\/p>\n

A\u00a0hematopoiese<\/strong>\u00a0\u00e9 o processo de forma\u00e7\u00e3o de novos elementos celulares do sangue em vertebrados.<\/p>\n

O processo come\u00e7a quando as c\u00e9lulas-tronco se tornam c\u00e9lulas progenitoras comprometidas que eventualmente se desenvolvem em c\u00e9lulas diferenciadas totalmente maduras no sangue.<\/p>\n

Em humanos, os elementos celulares do sangue incluem gl\u00f3bulos vermelhos, gl\u00f3bulos brancos e tromb\u00f3citos.<\/p>\n

Essas c\u00e9lulas s\u00e3o todas derivadas das c\u00e9lulas-tronco hematopoi\u00e9ticas multipotentes (HSCs), que podem dar origem a diferentes tipos de c\u00e9lulas sangu\u00edneas.<\/p>\n

A\u00a0linfopoiese<\/strong>, em particular, \u00e9 a\u00a0hematopoiese<\/strong>\u00a0que leva \u00e0 forma\u00e7\u00e3o de\u00a0linf\u00f3citos<\/strong>.<\/p>\n

A este respeito, abaixo est\u00e1 a s\u00e9rie de etapas em linf\u00f3citos:<\/strong><\/p>\n

1)\u00a0<\/strong>Um hemocitoblasto d\u00e1 origem a c\u00e9lulas progenitoras linf\u00f3ides comuns (CLP).
\n2)\u00a0<\/strong>O CLP d\u00e1 origem a CFU-linf\u00f3cito (ou seja, a unidade formadora de col\u00f4nia que leva \u00e0 forma\u00e7\u00e3o de linf\u00f3citos).
\n3)\u00a0<\/strong>O CFU-linf\u00f3cito d\u00e1 origem a linfoblastos.
\n4)<\/strong>\u00a0Os linfoblastos se desenvolvem em prolinf\u00f3citos.
\n5)<\/strong>\u00a0Os pr\u00f3-linf\u00f3citos se desenvolvem em linf\u00f3citos.<\/p><\/blockquote>\n

Os linf\u00f3citos podem ser agrupados em dois:<\/strong>\u00a0linf\u00f3citos pequenos e grandes. Os linf\u00f3citos pequenos incluem linf\u00f3citos B e linf\u00f3citos T.<\/p>\n

Os\u00a0linf\u00f3citos B<\/strong>\u00a0est\u00e3o envolvidos na produ\u00e7\u00e3o de anticorpos na resposta imune humoral.
\nOs\u00a0linf\u00f3citos T<\/strong>\u00a0participam da resposta imune mediada por c\u00e9lulas. Os grandes linf\u00f3citos incluem as c\u00e9lulas natural killer, ou seja, c\u00e9lulas envolvidas na resposta imune inata dos vertebrados.<\/p><\/blockquote>\n

Fonte:<\/strong>\u00a0www.sciencedirect.com\/www.oxfordreference.com\/www.nature.com\/www.wisegeek.org\/accessmedicine.mhmedical.com\/www.merriam-webster.com\/www.biologyonline.com<\/p>\n","protected":false},"excerpt":{"rendered":"

Linfopoiese – Defini\u00e7\u00e3o A\u00a0linfopoiese\u00a0\u00e9 uma sequ\u00eancia de eventos rigidamente regulada que leva \u00e0 express\u00e3o de um receptor de ant\u00edgeno funcional na superf\u00edcie do linf\u00f3cito. A\u00a0linfopoiese\u00a0\u00e9 a forma\u00e7\u00e3o de\u00a0linf\u00f3citos\u00a0ou\u00a0tecido linf\u00e1tico. A\u00a0linfopoiese\u00a0\u00e9 o processo de produ\u00e7\u00e3o de\u00a0linf\u00f3citos, que ocorre na medula \u00f3ssea, bem como nos g\u00e2nglios linf\u00e1ticos, ba\u00e7o, gl\u00e2ndula timo e parede intestinal. Linfopoiese\u00a0\u00e9 o processo no […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[84],"tags":[],"class_list":["post-143573","post","type-post","status-publish","format-standard","hentry","category-saude"],"acf":[],"yoast_head":"\nLinfopoiese, Processo, Produ\u00e7\u00e3o, Linf\u00f3citos, O que \u00e9 Linfopoiese<\/title>\n<meta name=\"description\" content=\"Linfopoiese, Processo, Produ\u00e7\u00e3o, Linf\u00f3citos, O que \u00e9, Hematopoiese, C\u00e9lulas, Tronco, Medula, \u00d3ssea, Sangue, Fun\u00e7\u00e3o, Anticorpo, Defini\u00e7\u00e3o Linfopoiese\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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