{"id":25104,"date":"2015-11-23T00:00:00","date_gmt":"2015-11-23T00:00:00","guid":{"rendered":"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/uncategorized\/citocalasinas-4\/"},"modified":"2026-09-01T17:43:22","modified_gmt":"2026-09-01T17:43:22","slug":"citocalasinas-4","status":"publish","type":"post","link":"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/biologia-2\/citocalasinas-4\/","title":{"rendered":"Citocalasinas"},"content":{"rendered":"\n&nbsp;\n\n<strong>Citocalasinas &#8211; O que \u00e9<\/strong>\n\n<strong>Citocalasinas<\/strong>\u00a0(Cytos gregos, celulares; chalasis, relaxamento) s\u00e3o uma fam\u00edlia de metab\u00f3litos f\u00fangicos com estrutura molecular complexa e diversificada e v\u00e1rias atividades biol\u00f3gicas.\n\nA estrutura comum motivo partilhado entre diferentes membros \u00e9 um n\u00facleo de isoindolona bicycic r\u00edgida, que est\u00e1 fundido com um macrociclo.\n\nAs diferentes estruturas macroc\u00edclicas.\n\nAcredita-se que desempenham um papel na importante determina\u00e7\u00e3o da atividade biol\u00f3gica.\n\n<strong>Citocalasinas &#8211; Caracter\u00edsticas<\/strong>\n\n<strong>Citocalasinas\u00a0<\/strong>s\u00e3o f\u00fangicas metabolitos que t\u00eam a capacidade de se ligar a actina e filamentos bloco de polimeriza\u00e7\u00e3o e o alongamento da actina.\n\nComo resultado da inibi\u00e7\u00e3o da polimeriza\u00e7\u00e3o da actina,\u00a0<strong>Citocalasinas<\/strong>\u00a0pode alterar celular morfologia, inibem processos celulares como a divis\u00e3o celular, e at\u00e9 levar as c\u00e9lulas a sofrer apoptose.\n\n<strong>Citocalasinas\u00a0<\/strong>t\u00eam a capacidade de permear as membranas celulares, prevenir a transloca\u00e7\u00e3o celular e c\u00e9lulas causam para extirpar.\n\n<strong>Citocalasinas<\/strong>\u00a0tamb\u00e9m pode ter um efeito sobre outros aspectos dos processos biol\u00f3gicos n\u00e3o relacionados com a polimeriza\u00e7\u00e3o da actina. Por exemplo, citocalasina A e citocalasina B pode tamb\u00e9m inibir o transporte de monossacar\u00eddeos atrav\u00e9s da membrana celular, citocalasina H tem sido encontrado para regular o crescimento da planta, citocalasina D inibe a s\u00edntese proteica e citocalasina E previne a angiog\u00e9nese.\n\n<strong>Liga\u00e7\u00e3o a filamentos de actina<\/strong>\n\n<strong>Citocalasinas<\/strong>\u00a0s\u00e3o conhecidos para ligar os farpados, de crescimento r\u00e1pido, mais extremidades de microfilamentos, que, em seguida, bloqueia tanto a montagem e desmontagem de mon\u00f3meros de actina individuais a partir da extremidade acoplado.\n\nUma vez ligado, Citocalasinas essencialmente coroar o fim do novo filamento de actina. Uma citocalasina ir\u00e1 ligar-se a um filamento de actina.\n\nEstudos realizados com citocalasina D (CD) descobriram que a forma\u00e7\u00e3o de d\u00edmeros de CD-actina, cont\u00eam actina ATP-dependente.\n\nEstes d\u00edmeros de CD-actina s\u00e3o reduzidos para o CD- mon\u00f3meros de actina, como resultado da hidr\u00f3lise de ATP.\n\nO mon\u00f4mero de CD-actina resultante pode se ligam ATP-actina mon\u00f4mero para reformar o CD-actina d\u00edmero. CD \u00e9 muito eficaz, apenas baixas concentra\u00e7\u00f5es (0,2 mM) s\u00e3o necess\u00e1rias para prevenir ruffling membrana e perturbar treadmilling.\n\nOs efeitos de muitos Citocalasinas diferentes sobre os filamentos de actina foram analisados e as concentra\u00e7\u00f5es mais elevadas (2-20 mM) de CD foram encontrados para ser necess\u00e1ria para remover as fibras de stress.\n\nEm contraste, latrunculina inibe a polimeriza\u00e7\u00e3o de filamentos de actina por liga\u00e7\u00e3o aos mon\u00f3meros de actina.\n\n<strong>Usos e aplica\u00e7\u00f5es de Citocalasinas<\/strong>\n\nMicrofilamentos de actina t\u00eam sido amplamente estudados usando Citocalasinas. Devido \u00e0 sua natureza qu\u00edmica,\u00a0<strong>Citocalasinas<\/strong>\u00a0pode ajudar os pesquisadores a entender a import\u00e2ncia de actina em v\u00e1rios processos biol\u00f3gicos.\n\nO uso de\u00a0<strong>Citocalasinas<\/strong>\u00a0tem permitido aos pesquisadores entender melhor a polimeriza\u00e7\u00e3o de actina, motilidade celular, bagun\u00e7ando, a divis\u00e3o celular, contra\u00e7\u00e3o e rigidez da c\u00e9lula.\n\nO\u00a0<strong>uso de Citocalasinas<\/strong>\u00a0foi t\u00e3o importante para a compreens\u00e3o do citoesqueleto e movimento de muitos outros processos biol\u00f3gicos, os pesquisadores criaram duas Citocalasinas sint\u00e9ticos.\n\nCitocalasina encontrou aplica\u00e7\u00e3o pr\u00e1tica em tromboelastometria (TEM) Os ensaios de sangue completo para a avalia\u00e7\u00e3o do fibrinog\u00e9nio e desordens de polimeriza\u00e7\u00e3o de fibrina no ensaio FIBTEM em Rotem.\n\nEste teste \u00e9 baseado no princ\u00edpio de que citocalasina D inibe muito eficazmente das plaquetas. Por inibi\u00e7\u00e3o da fun\u00e7\u00e3o dos elementos contr\u00e1cteis.\n\nA inibi\u00e7\u00e3o de plaquetas \u00e9 mais eficaz do que quando as plaquetas s\u00e3o bloqueados por GPIIb\/IIIa antagonistas, in vitro e os dados cl\u00ednicos indicam que a resist\u00eancia do co\u00e1gulo em aumentos FIBTEM num fibrinog\u00e9nio maneira dependente da concentra\u00e7\u00e3o, independentemente da contagem de plaquetas.\n\nPor conseguinte, a defici\u00eancia de fibrinog\u00e9nio ou desordens de polimeriza\u00e7\u00e3o de fibrina pode ser rapidamente detectado.\n\n<strong>Estruturas qu\u00edmicas<\/strong>\n<p class=\"imagem\"><strong><img loading=\"lazy\" decoding=\"async\" title=\"Citocalasinas\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/Citoca1.jpg\" alt=\"Citocalasinas\" width=\"375\" height=\"200\" \/>\nA citocalasina<\/strong><\/p>\n<p class=\"imagem\"><strong><img loading=\"lazy\" decoding=\"async\" title=\"Citocalasinas\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/Citoca2.jpg\" alt=\"Citocalasinas\" width=\"380\" height=\"201\" \/>\nCitocalasina B<\/strong><\/p>\n<p class=\"imagem\"><strong><img loading=\"lazy\" decoding=\"async\" title=\"Citocalasinas\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/Citoca3.jpg\" alt=\"Citocalasinas\" width=\"371\" height=\"238\" \/>\nCitocalasina C<\/strong><\/p>\n<p class=\"imagem\"><strong><img loading=\"lazy\" decoding=\"async\" title=\"Citocalasinas\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/Citoca4.jpg\" alt=\"Citocalasinas\" width=\"372\" height=\"237\" \/>\nCitocalasina D<\/strong><\/p>\n<p class=\"imagem\"><strong><img loading=\"lazy\" decoding=\"async\" title=\"Citocalasinas\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/Citoca5.jpg\" alt=\"Citocalasinas\" width=\"421\" height=\"207\" \/>\nE citocalasina<\/strong><\/p>\n<p class=\"imagem\"><strong><img loading=\"lazy\" decoding=\"async\" title=\"Citocalasinas\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/Citoca6.jpg\" alt=\"Citocalasinas\" width=\"383\" height=\"208\" \/>\nCitocalasina F<\/strong><\/p>\n<p class=\"imagem\"><strong><img loading=\"lazy\" decoding=\"async\" title=\"Citocalasinas\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/Citoca7.jpg\" alt=\"Citocalasinas\" width=\"373\" height=\"245\" \/>\nCitocalasina H<\/strong><\/p>\n<p class=\"imagem\"><strong><img loading=\"lazy\" decoding=\"async\" title=\"Citocalasinas\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/Citoca8.jpg\" alt=\"Citocalasinas\" width=\"371\" height=\"208\" \/>\nCitocalasina J<\/strong><\/p>\n<strong>Fonte:<\/strong>\u00a0www.scripps.edu\/en.wikipedia.org\/www.caymanchem.com\/www.sigmaaldrich.com\/www.enzolifesciences.com\/core.ac.uk\n","protected":false},"excerpt":{"rendered":"<p>Citocalasinas, Filamentos, Actina, Biologia, Estrutura, Subst\u00e2ncias, Caracter\u00edsticas, Citoesqueleto, O que \u00e9, Citocalasinas<\/p>\n","protected":false},"author":1,"featured_media":2017,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[46],"tags":[],"class_list":["post-25104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biologia-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - 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