{"id":18945,"date":"2015-11-23T00:00:00","date_gmt":"2015-11-23T00:00:00","guid":{"rendered":"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/uncategorized\/celulas-natural-killer-3\/"},"modified":"2026-09-01T15:19:08","modified_gmt":"2026-09-01T15:19:08","slug":"celulas-natural-killer-3","status":"publish","type":"post","link":"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/biologia-2\/celulas-natural-killer-3\/","title":{"rendered":"C\u00e9lulas Natural Killer"},"content":{"rendered":"\n<strong>C\u00e9lulas Natural Killer &#8211; Defini\u00e7\u00e3o<\/strong>\n\n<strong>C\u00e9lulas NK (natural killer)\u00a0<\/strong>s\u00e3o parte do sistema imune inato. Como as c\u00e9lulas T citot\u00f3xicas, c\u00e9lulas NK destroem c\u00e9lulas infectadas por virus induzindo-as a sofrer apoptose.\n\nAo contr\u00e1rio das c\u00e9lulas T citot\u00f3xicas, por\u00e9m, c\u00e9lulas NK n\u00e3o expressam receptores de ant\u00edgenos, que permitem reconhecer prote\u00ednas virais na superf\u00edcie das c\u00e9lulas infectadas.\n\nTipo de c\u00e9lula imune que possui gr\u00e2nulos (pequenas part\u00edculas) com enzimas que podem matar c\u00e9lulas tumorais ou c\u00e9lulas infectadas com um v\u00edrus.\n\nUma c\u00e9lula NK \u00e9 um tipo de gl\u00f3bulo branco.\n\n<strong>O que \u00e9 uma C\u00e9lulas Natural Killer (NK) ?<\/strong>\n\nUma\u00a0<strong>C\u00e9lula Natural Killer &#8211; assassino natural ou c\u00e9lula NK<\/strong>\u00a0&#8211; \u00e9 um gl\u00f3bulo branco que atua como a primeira linha de defesa do sistema imunol\u00f3gico contra invasores externos como tumores, bact\u00e9rias e v\u00edrus.\n\nAs c\u00e9lulas NK s\u00e3o conhecidas como \u201c<strong>natural killers<\/strong>\u201d porque n\u00e3o precisam reagir a ant\u00edgenos espec\u00edficos, elas apenas precisam reconhecer que uma c\u00e9lula \u00e9 estranha e n\u00e3o pertence a ela.\n\nComo essas c\u00e9lulas s\u00e3o t\u00e3o poderosas, o corpo tem uma s\u00e9rie de etapas que s\u00e3o projetadas para impedir que as c\u00e9lulas NK corram soltas e acidentalmente ataquem seu hospedeiro.\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-154938 size-full aligncenter\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/Celula1ok-1.jpg\" alt=\"\" width=\"764\" height=\"253\" \/><strong>Uma c\u00e9lula natural killer \u00e9 um tipo de linf\u00f3cito, um gl\u00f3bulo branco<\/strong><\/p>\nPara entender como as\u00a0<strong>c\u00e9lulas assassinas naturais<\/strong>\u00a0funcionam, \u00e9 necess\u00e1rio fazer uma breve incurs\u00e3o na biologia. Essas c\u00e9lulas procuram prote\u00ednas conhecidas como Ant\u00edgenos Leucocit\u00e1rios Humanos (HLAs), que s\u00e3o exibidos na superf\u00edcie de outras c\u00e9lulas. Se uma c\u00e9lula natural killer reconhece as prote\u00ednas HLA como pertencentes ao &#8220;eu&#8221;, ela ignora a c\u00e9lula, presumindo que ela pertence. Se, por outro lado, os HLAs parecem estranhos, a c\u00e9lula natural killer libera toxinas que matam a c\u00e9lula estranha.\n\nOs HLAs s\u00e3o expressos por meio do Complexo Principal de Histocompatibilidade, um grupo de genes localizados no sexto cromossomo. O Complexo Principal de Histocompatibilidade \u00e9 \u201cprincipal\u201d porque desempenha uma regra cr\u00edtica na aceita\u00e7\u00e3o ou rejei\u00e7\u00e3o de tecidos transplantados. Se os HLAs de um \u00f3rg\u00e3o n\u00e3o corresponderem, o corpo o rejeitar\u00e1, com as c\u00e9lulas assassinas naturais se movendo para proteger o corpo de um invasor percebido.\n\nUma\u00a0<strong>c\u00e9lula natural killer<\/strong>\u00a0tem v\u00e1rios receptores que usa para reunir informa\u00e7\u00f5es sobre as c\u00e9lulas com as quais entra em contato. Normalmente, pelo menos um receptor espec\u00edfico deve ser ativado para que uma c\u00e9lula natural killer entre em a\u00e7\u00e3o. Outras c\u00e9lulas do sistema imunol\u00f3gico tamb\u00e9m podem estar envolvidas na resposta, com o sistema imunol\u00f3gico entrando em a\u00e7\u00e3o para tratar de problemas de sa\u00fade emergentes.\n\nA\u00a0<strong>c\u00e9lula natural assassina<\/strong>\u00a0funciona agarrando-se \u00e0 c\u00e9lula suspeita e essencialmente injetando-a com citotoxinas, subst\u00e2ncias projetadas para matar c\u00e9lulas.\n\n\u00c0s vezes, as coisas d\u00e3o errado com as c\u00e9lulas assassinas naturais. Por exemplo, \u00e0s vezes uma mulher carrega um beb\u00ea com HLAs incompat\u00edveis e as c\u00e9lulas assassinas naturais pensam que o feto \u00e9 perigoso.\n\nNesses casos, v\u00e1rios tratamentos m\u00e9dicos s\u00e3o usados com o objetivo de permitir que o beb\u00ea se desenvolva para que a mulher possa carreg\u00e1-lo at\u00e9 o fim.\n\nAs\u00a0<strong>c\u00e9lulas assassinas naturais<\/strong>\u00a0tamb\u00e9m podem se tornar malignas, desenvolvendo linfoma, um tipo de c\u00e2ncer. O linfoma de c\u00e9lulas NK pode ser extremamente dif\u00edcil de tratar.\n\n<strong>C\u00e9lulas assassinas naturais<\/strong>\n\n<strong>C\u00e9lulas assassinas naturais<\/strong>\u00a0(tamb\u00e9m conhecidas como c\u00e9lulas NK, c\u00e9lulas K, e c\u00e9lulas assassinas) s\u00e3o um tipo de linf\u00f3cito (um gl\u00f3bulo branco) e um componente do sistema imune inato.\n\n<strong>C\u00e9lulas NK<\/strong>\u00a0desempenham um papel importante no hospedeiro-rejei\u00e7\u00e3o de tumores e c\u00e9lulas infectadas por v\u00edrus.\n\nAs c\u00e9lulas NK s\u00e3o citot\u00f3xicos; pequenos gr\u00e2nulos em seu citoplasma cont\u00eam prote\u00ednas especiais, como a perforina e proteases conhecidas como granzimas.\n\nAp\u00f3s a libera\u00e7\u00e3o na proximidade de um celular programado para matar, perforina formas poros na membrana celular da c\u00e9lula-alvo, atrav\u00e9s do qual os granzimas e mol\u00e9culas associadas podem entrar, induzindo a apoptose.\n<p class=\"imagem\"><img loading=\"lazy\" decoding=\"async\" title=\"C\u00e9lulas Natural Killer\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/ccelula23.jpg\" alt=\"C\u00e9lulas Natural Killer\" width=\"298\" height=\"253\" \/><\/p>\n<p class=\"imagem\"><img loading=\"lazy\" decoding=\"async\" title=\"C\u00e9lulas Natural Killer\" src=\"https:\/\/lab.fabricadelandings.com.br\/portalsaofrancisco\/wp-content\/uploads\/2026\/08\/ccelula25.jpg\" alt=\"C\u00e9lulas Natural Killer\" width=\"315\" height=\"319\" \/><\/p>\nA distin\u00e7\u00e3o entre a apoptose e lise das c\u00e9lulas \u00e9 importante em imunologia \u2013 lise de uma c\u00e9lula infectada por v\u00edrus apenas iria libertar as part\u00edculas virais, enquanto que a apoptose leva \u00e0 destrui\u00e7\u00e3o do v\u00edrus dentro.\n\nAs c\u00e9lulas NK s\u00e3o ativados em resposta a interfer\u00f5es ou citocinas derivadas de macr\u00f3fagos.\n\nEles servem para conter as infec\u00e7\u00f5es virais, enquanto a resposta imune adaptativa \u00e9 gerar c\u00e9lulas T citot\u00f3xicas espec\u00edficas para o antig\u00e9nio que pode limpar a infec\u00e7\u00e3o.\n\nPacientes com defici\u00eancia em c\u00e9lulas NK revelar-se altamente suscet\u00edvel a fases iniciais da infec\u00e7\u00e3o pelo v\u00edrus da herpes.\n\n<strong>C\u00e9lulas Natural Killer &#8211; Resumo<\/strong>\n\nAs\u00a0<strong>c\u00e9lulas natural killer (NK)<\/strong>\u00a0s\u00e3o linf\u00f3citos efetores do sistema imunol\u00f3gico inato que controlam v\u00e1rios tipos de tumores e infec\u00e7\u00f5es microbianas, limitando sua dissemina\u00e7\u00e3o e subsequente dano ao tecido.\n\nPesquisas recentes destacam o fato de que as c\u00e9lulas NK tamb\u00e9m s\u00e3o c\u00e9lulas regulat\u00f3rias envolvidas em intera\u00e7\u00f5es rec\u00edprocas com c\u00e9lulas dendr\u00edticas, macr\u00f3fagos, c\u00e9lulas T e c\u00e9lulas endoteliais.\n\nAs c\u00e9lulas NK podem, portanto, limitar ou exacerbar as respostas imunol\u00f3gicas.\n\nEmbora as c\u00e9lulas NK possam parecer redundantes em v\u00e1rias condi\u00e7\u00f5es de desafio imunol\u00f3gico em humanos, a manipula\u00e7\u00e3o das c\u00e9lulas NK parece promissora nos esfor\u00e7os para melhorar o transplante de \u00f3rg\u00e3os hematopoi\u00e9ticos e s\u00f3lidos, promover imunoterapia antitumoral e controlar dist\u00farbios inflamat\u00f3rios e autoimunes.\n\n<strong>Fonte:<\/strong>\u00a0www.cancer.gov\/www.sciencedaily.com\/www.wisegeekhealth.com\/www.thermofisher.com\/www.nature.com\n","protected":false},"excerpt":{"rendered":"<p>C\u00e9lulas Natural Killer, Assassinas, O que \u00e9, NK, Localiza\u00e7\u00e3o, Sistema, Imune, Tipo, Linf\u00f3cito, Papel, Endometriais, Defesa, C\u00e9lulas Natural Killer<\/p>\n","protected":false},"author":1,"featured_media":1912,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[46],"tags":[],"class_list":["post-18945","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biologia-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - 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